Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats

Authors

1 Division of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2 Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Abstract

Objective(s)
This study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats.
Materials and Methods
Twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. After 2 weeks, serum total cholesterol, triglycerides, HDL-c, LDL-c and VLDL-c concentrations were assayed and liver sections examined for fatty liver changes. Data were analyzed by ANOVA method and         P< 0.05 was considered significant.
Results
Dexamethasone increased all lipid parameters as compared to control (P< 0.05). Lipid parameters in group 3, were lower than group 2 (P< 0.05) except for HDL-c which remained statistically the same. Moderate fatty liver changes were observed in one third of rats in dexamethasone group. Rats in groups 1, 3 and 4 had no sign of fatty changes.
Conclusion
Niacin positively affects glucocorticoid-induced dyslipidemia and fatty liver changes in rats.

Keywords

References

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