The Effect of Iranian Shallot or Garlic Aqueous Extracts on Learning, Memory and Serum Biochemical Variables in Fructose-fed Wistar Rats


1 Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran

2 Department of Physiology, Shaheed Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

3 Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran


We determined the effect of a high fructose diet either alone or in combination with Iranian shallot or garlic extract on cognitive functions, plasma lipid profile, and the intraperitoneal glucose tolerance test (IPGTT).
Materials and Methods
Following induction of insulin resistance in fructose-fed rats (Fru-fed), they were randomly assigned to three subgroups. The first subgroup was kept as Fru-fed while the two other subgroups were daily treated by aqueous garlic or shallot extract.
Twelve weeks treatment with shallot or garlic significantly prevented the learning and memory deficits induced by fructose-feeding. Administration of garlic, but not shallot extract could significantly diminish the levels of cholesterol and low-density lipoprotein. Treatment with garlic or shallot extract can significantly improve the IPGTT in the Fru-fed rats.
The high fructose diet may contribute to spatial memory deficits. Iranian shallot or garlic extracts appear to improve learning and memory impairments in fructose-fed rats.


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