Protective Effect of Urtica dioica L. (Urticaceae) on Morphometric and Morphologic Alterations of Seminiferous Tubules in STZ Diabetic Rats

Authors

1 Department of Anatomy (Embryology and Histology), Golestan University of Medical Sciences, Gorgan, Iran

2 Department of Pathology, Golestan University of Medical Sciences, Gorgan, Iran

3 Department of Pharmacology, Golestan University of Medical Sciences, Gorgan, Iran

Abstract

Objective(s)
Urtica dioica L. has been known as a medicinal plant in the world. This study was conducted to determine the effects of the hydroalcoholic extract of Urtica dioica leaves on seminiferous tubules of diabetic rats.
Materials and Methods
Animals were allocated to control, diabetic and protective groups. Treated animals received extract of U. dioica (100 mg/ kg/ day) IP for the first 5 days and STZ injection on the 6th day. After 5 weeks, testes removed and stained with H&E technique.
Results
Tubular cell disintegration, sertoli and spermatogonia cell vacuolization, and decrease in sperm concentration observed in diabetic in comparison with control and protective groups. External seminiferous tubular diameter and seminiferous epithelial height significantly reduced (P< 0.05) in diabetic compared with controls, and these parameters increased (P< 0.05) in the treated compared with diabetics.
Conclusion
Hydroalcoholic extract of U. dioica, before induction of diabetes; has protective role on seminiferous tubules alterations.

Keywords

References

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Iranian Journal of Basic Medical Sciences
Volume 14, Issue 5 - Serial Number 5
September 2011
Pages 472-477

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