Evaluation of Hair Growth Activity of Buxus wallichiana Baill Extract in Rats

Document Type : Original Article

Authors

1 Department of Pharmacognosy, Sree Siddhaganga College of Pharmacy, Tumkur, Karnataka, India

2 Department of Pharmacognosy, Sri K.V.College of Pharmacy, Chickballapur, Karnataka, India

3 Department of Pharmacognosy, PES College of Pharmacy, Bangaluru, Karnataka, India

4 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India

5 Department of Pharmaceutical Biotechnology, Sri Krishan Chaitanya College of Pharmacy, Madanapalle, Andhra Pradesh, India

6 Department of Pharmacy, Andhra University, Vishakapatanam, Andhra Pradesh, India

Abstract

Objective(s)
The aim of this study was to evaluate antioxidant and hair growth activities of Buxus wallichiana Baill (Buxaceae).
Materials and methods
Petroleum ether, chloroform, methanol and aqueous extracts of Buxus wallichiana subjected to antioxidant activity by; 2, 2-diphenyl-1-picryl hydrazyl and nitric oxide methods. Methanol extract of Buxus wallichiana at 50, 100 mg/kg, ointment of methanol extract at 5 and 10% used for the evaluation of hair growth property.
Results
Methanol extract showed potential antioxidant activity. Methanol extract at 100 mg/kg showed consistent and significant increase in mean score of hair growth from day 3 to day 24. Whereas 50 mg/kg increased the mean score significantly, only from day 15 to day 24. When methanol extract at 10% applied topically, significant increase in mean hair score observed only from day 15, but at 5% showed considerable increase in mean hair score only from day 21 and 24, when compared to the control.
Conclusion
The result of this study suggests that Methanol extract of Buxus wallichiana possess good antioxidant and hair growth activity.

Keywords

References

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Iranian Journal of Basic Medical Sciences
Volume 11, Issue 4 - Serial Number 4
October 2009
Pages 236-241

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