Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231

Document Type : Original Article


Department of Clinical Biochemistry, Cancer Research Laboratory, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


1. Lambrechts S, Decloedt J, Neven P. Breast cancer prevention: Lifestyle
changes and chemoprevention. Acta Clin Belg 2011; 66:283-
2. Kasibhatla S, Tseng B. Why target apoptosis in cancer treatment?
Mol Cancer Ther 2003; 2:573-580.
3. Brash AR. Lipoxygenases: Occurrence, functions, catalysis, and acquisition
of substrate. J Biol Chem 1999; 274:23679-23682.
4. Brash AR, Jisaka M, Boeglin WE, Chang MS, Keeney DS, Nanney LB,
Investigation of a second 15s-lipoxygenase in humans and its
expression in epithelial tissues. Adv Exp Med Biol 1999; 469:83-
5. Shureiqi I, Wojno KJ, Poore JA, Reddy RG, Moussalli MJ, Spindler
et al
. Decreased 13-s-hydroxyoctadecadienoic acid levels and
15-lipoxygenase-1 expression in human colon cancers. Carcinogenesis
1999; 20:1985-1995.
6. Yuan H, Li MY, Ma LT, Hsin MK, Mok TS, Underwood MJ, Chen GG.
15-lipoxygenases and its metabolites 15(s)-hete and 13(s)-hode
in the development of non-small cell lung cancer. Thorax 2010;
7. Nixon JB, Kim KS, Lamb PW, Bottone FG, Eling TE. 15-lipoxygenase-1
has anti-tumorigenic effects in colorectal cancer. Prostaglandins
Leukot Essent Fatty Acids 2004; 70:7-15.
8. Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V,
et al.
. Reduced 15s-lipoxygenase-2 expression in esophageal cancer
specimens and cells and upregulation
in vitro
by the cyclooxygenase-
2 inhibitor, ns398. Neoplasia 2003; 5:121-127.
9. Hennig R, Kehl T, Noor S, Ding XZ, Rao SM, Bergmann F,
et al.
15-lipoxygenase-1 production is lost in pancreatic cancer and
overexpression of the gene inhibits tumor cell growth. Neoplasia
2007; 9:917-926.
10. Jiang WG, Watkins G, Douglas-Jones A, Mansel RE. Reduction of isoforms
of 15-lipoxygenase (15-lox)-1 and 15-lox-2 in human breast
cancer. Prostaglandins Leukot Essent Fatty Acids 2006; 74:235-
11. Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE,
et al
15-lox-1: A novel molecular target of nonsteroidal anti-inflammatory
drug-induced apoptosis in colorectal cancer cells. J Natl
Cancer Inst 2000; 92:1136-1142.
12. Hsi LC, Xi X, Lotan R, Shureiqi I, Lippman SM. The histone deacetylase
inhibitor suberoylanilide hydroxamic acid induces apoptosis
via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Cancer Res 2004; 64:8778-8781.
13. Kumar KA, Arunasree KM, Roy KR, Reddy NP, Aparna A, Reddy GV,
Reddanna P. Effects of (15s)-hydroperoxyeicosatetraenoic acid
and (15s)-hydroxyeicosatetraenoic acid on the acute- lymphoblastic-
leukaemia cell line jurkat: Activation of the fas-mediated
death pathway. Biotechnol Appl Biochem 2009; 52:121-133.
14. Shureiqi I, Chen D, Lotan R, Yang P, Newman RA, Fischer SM,
15-lipoxygenase-1 mediates nonsteroidal anti-inflammatory
drug-induced apoptosis independently of cyclooxygenase-2 in
colon cancer cells. Cancer Res 2000; 60:6846-6850.
15. Shureiqi I, Wu Y, Chen D, Yang XL, Guan B, Morris JS,
et al
. The critical
role of 15-lipoxygenase-1 in colorectal epithelial cell terminal
differentiation and tumorigenesis. Cancer Res 2005; 65:11486-
16. Pasqualini ME, Heyd VL, Manzo P, Eynard AR. Association between
e-cadherin expression by human colon, bladder and breast cancer
cells and the 13-hode:15-hete ratio. A possible role of their
metastatic potential. Prostaglandins Leukot Essent Fatty Acids
2003; 68:9-16.
17. Cimen I, Tuncay S, Banerjee S. 15-lipoxygenase-1 expression suppresses
the invasive properties of colorectal carcinoma cell lines
hct-116 and ht-29. Cancer Sci 2009; 100:2283-2291.
18. Youssef J, Badr M. Peroxisome proliferator-activated receptors
and cancer: Challenges and opportunities. Br J Pharmacol
19. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors
and lipid physiology: Opening the x-files. Science 2001; 294:1866-
20. Foreman JE, Sharma AK, Amin S, Gonzalez FJ, Peters JM. Ligand
activation of peroxisome proliferator-activated receptor-beta/
delta (pparbeta/delta) inhibits cell growth in a mouse mammary
gland cancer cell line. Cancer Lett 2010; 288:219-225.
21. Zuo X, Wu Y, Morris JS, Stimmel JB, Leesnitzer LM, Fischer SM,
. Oxidative metabolism of linoleic acid modulates ppar-beta/
delta suppression of ppar-gamma activity. Oncogene 2006;
22. Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS.
Expression of cloned human reticulocyte 15-lipoxygenase and
immunological evidence that 15-lipoxygenases of different cell
13(S)-HODE Tavakoli-Yaraki M et al
Iran J Basic Med Sci; Vol. 16, No. 4, Apr 2013
types are related. J Biol Chem 1990; 265:5113-5120.
23. Mahipal SV, Subhashini J, Reddy MC, Reddy MM, Anilkumar K, Roy
et al
. Effect of 15-lipoxygenase metabolites, 15-(s)-hpete and
15-(s)-hete on chronic myelogenous leukemia cell line k-562: Reactive
oxygen species (ros) mediate caspase-dependent apoptosis.
Biochem Pharmacol 2007; 74:202-214.
24. Kim JH, Chang JH, Yoon JH, Lee JG, Bae JH, Kim KS. 15-lipoxygenase-1
induced by interleukin-4 mediates apoptosis in oral cavity cancer
cells. Oral Oncol 2006; 42:825-830.
25. Viita H, Pacholska A, Ahmad F, Tietavainen J, Naarala J, Hyvarinen
et al.
15-lipoxygenase-1 induces lipid peroxidation and apoptosis,
and improves survival in rat malignant glioma.
In Vivo
26. Glinghammar B, Skogsberg J, Hamsten A, Ehrenborg E. Ppardelta
activation induces cox-2 gene expression and cell proliferation
in human hepatocellular carcinoma cells. Biochem Biophys Res
Commun 2003; 308:361-368.
27. Stephen RL, Gustafsson MC, Jarvis M, Tatoud R, Marshall BR, Knight
et al
. Activation of peroxisome proliferator-activated receptor
delta stimulates the proliferation of human breast and prostate
cancer cell lines. Cancer Res 2004; 64:3162-3170.
28. Yin Y, Russell RG, Dettin LE, Bai R, Wei ZL, Kozikowski AP,
et al
. Peroxisome
proliferator-activated receptor delta and gamma agonists
differentially alter tumor differentiation and progression during
mammary carcinogenesis. Cancer Res 2005; 65:3950-3957.
29. Ghosh M, Ai Y, Narko K, Wang Z, Peters JM, Hla T. Ppardelta is protumorigenic
in a mouse model of cox-2-induced mammary cancer.
Prostaglandins Other Lipid Mediat 2009; 88:97-100.
30. Glasgow WC, Hui R, Everhart AL, Jayawickreme SP, Angerman-
Stewart J, Han BB,
et al.
The linoleic acid metabolite, (13s)-hydroperoxyoctadecadienoic
acid, augments the epidermal growth
factor receptor signaling pathway by attenuation of receptor
dephosphorylation. Differential response in syrian hamster embryo
tumor suppressor phenotypes. J Biol Chem 1997; 272:19269-
31. Sauer LA, Dauchy RT, Blask DE, Armstrong BJ, Scalici S. 13-hydroxyoctadecadienoic
acid is the mitogenic signal for linoleic
acid-dependent growth in rat hepatoma 7288ctc
in vivo
. Cancer
Res 1999; 59:4688-4692.
32. Kelavkar UP, Cohen C, Kamitani H, Eling TE, Badr KF. Concordant
induction of 15-lipoxygenase-1 and mutant p53 expression in human
prostate adenocarcinoma: Correlation with gleason staging.
Carcinogenesis 2000; 21:1777-1787.
33. Kelavkar UP, Nixon JB, Cohen C, Dillehay D, Eling TE, Badr KF. Overexpression
of 15-lipoxygenase-1 in pc-3 human prostate cancer
cells increases tumorigenesis. Carcinogenesis 2001; 22:1765-1773.