The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis

Authors

1 Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal

2 Department of Zootechnics, University of Trás-os-Montes and Alto Douro, 911 Vila Real, Portugal Center for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, PortugalCentre for the Research and Technology

3 Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, PortugalCenter for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, PortugalCentre for the Research and Technology

4 Chemistry Research Center, CQ-VR, University of Trás-os-Montes and Alto Douro, 5001-801, Vila Real, Portugal

Abstract

Objective(s):Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice.
Materials and Methods: The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks.
Results:Animals from groups BBN+GT and BBN only developed preneoplastic lesions.
Conclusion:We did not observe any effects by GT infusion administration on urinary bladder cancer development.

Keywords

References

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Iranian Journal of Basic Medical Sciences
Volume 17, Issue 2 - Serial Number 2
February 2014
Pages 145-148

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