1. Lu JJ, Zhang X, Abudukeyoumu A, Lai ZZ, Hou DY, Wu JN, et al. Active estrogen-succinate metabolism promotes heme accumulation and increases the proliferative and invasive potential of endometrial cancer cells. Biomolecules 2023; 13:1097-1114.
2. Emons G, Fleckenstein G, Hinney B, Huschmand A, Heyl W. Hormonal interactions in endometrial cancer. Endocr Relat Cancer 2000; 7:227-242.
3. Merritt MA, Cramer DW. Molecular pathogenesis of endometrial and ovarian cancer. Cancer Biomark 2011; 9:287-305.
4. Malik TY, Chishti U, Aziz AB, Sheikh I. Comparison of risk factors and survival of type 1 and type II endometrial cancers. Pak J Med Sci 2016; 32:886-890.
5. Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z. Lipid metabolism and cancer. J Exp Med 2021; 218:1-17.
6. Hutt S, Tailor A, Ellis P, Michael A, Butler-Manuel S, Chatterjee J. The role of biomarkers in endometrial cancer and hyperplasia: A literature review. Acta Oncol 2019; 58:342-352.
7. Mutter GL, Monte NM, Neuberg D, Ferenczy A, Eng C. Emergence, involution, and progression to carcinoma of mutant clones in normal endometrial tissues. Cancer Res 2014; 74:2796-2802.
8. Abd El-Maqsoud NM, El-Gelany S. Differential expression patterns of pten in cyclic, hyperplastic and malignant endometrium: its relation with er, pr and clinicopathological parameters. J Egypt Natl Canc Inst 2009; 21:323-331.
9. Joshi A, Wang H, Jiang G, Douglas W, Chan JS, Korach KS, Ellenson LH. Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α. Am J Pathol 2012; 180:2536-2547.
10. Bhan A, Hussain I, Ansari KI, Bobzean SAM, Perrotti LI, Mandal SS. Histone methyltransferase ezh2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-a and diethylstilbestrol. J Mol Biol 2014; 426:3426-3441.
11. Nanjappa MK, Mesa AM, Medrano TI, Jefferson WN, DeMayo FJ, Williams CJ, et al. The histone methyltransferase EZH2 is required for normal uterine development and function in mice. Biol Reprod 2019; 101:306-317.
12. Eskander RN, Ji T, Huynh B, Wardeh R, Randall LM, Hoang B. Inhibition of enhancer of zeste homolog 2 (EZH2) expression is associated with decreased tumor cell proliferation, migration, and invasion in endometrial cancer cell lines. Int J Gynecol Cancer 2013; 23:997-1005.
13. Yang Q, Nair S, Laknaur A, Ismail N, Diamond MP, Al-Hendy A. The polycomb group protein ezh2 impairs dna damage repair gene expression in human uterine fibroids. Biol Reprod 2016; 94:69-83.
14. Gu Y, Zhang J, Guan H. Expression of EZH2 in endometrial carcinoma and its effects on proliferation and invasion of endometrial carcinoma cells. Oncol Lett 2017; 14:7191-7196.
15. Jiang P, Jia M, Hu J, Huang Z, Deng Y, Lai L, et al. Prognostic value of ki67 in patients with stage 1-2 endometrial cancer: validation of the cut-off value of ki67 as a predictive factor. Onco Targets Ther 2020; 13:10841-10850.
16. Ferrandina G, Ranelletti FO, Gallotta V, Martinelli E, Zannoni GF, Gessi M, Scambia G. Expression of cyclooxygenase-2 (COX-2), receptors for estrogen (ER), and progesterone (PR), p53, ki67, and neu protein in endometrial cancer. Gynecol Oncol 2005; 98:383-389.
17. Ghalib Farhood R, Abd Ali Al-Humairi I. Immunohistochemical study of ki-67 in hyperplastic and endometrium carcinoma: a comparative study. Arch Razi Inst 2022; 77:229-234.
18. Ataabadi MS, Bahmanpour S, Yousefinejad S, Alaee S. Blood volatile organic compounds as potential biomarkers for poly cystic ovarian syndrome (PCOS): An animal study in the PCOS rat model. J Steroid Biochem Mol Biol 2023; 226:106215.
19. Korovesis D, Rubio-Tomás T, Tavernarakis N. Oxidative stress in age-related neurodegenerative diseases: An overview of recent tools and findings. Antioxidants (Basel) 2023; 12:1-21.
20. Bolton JL. Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens. Toxicology 2002; 177:55-65.
21. Punnonen R, Kudo R, Punnonen K, Hietanen E, Kuoppala T, Kainulainen H, et al. Activities of antioxidant enzymes and lipid peroxidation in endometrial cancer. Eur J Cancer 1993; 29:266-269.
22. Fader AN, Arriba LN, Frasure HE, von Gruenigen VE. Endometrial cancer and obesity: Epidemiology, biomarkers, prevention and survivorship. Gynecol Oncol 2009; 114:121-127.
23. Burgovа EN, Khristidis YI, Kurkov AV, Mikoyan VD, Shekhter AB, Adamyan LV, et al. The inhibiting effect of dinitrosyl iron complexes with thiol-containing ligands on the growth of endometrioid tumours in rats with experimental endometriosis. Cell Biochem Biophys 2019; 77:69-77.
24. Rangel-Zuñiga OA, Cruz-Teno C, Haro C, Quintana-Navarro GM, Camara-Martos F, Perez-Martinez P, et al. Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers. Mech Ageing Dev 2017; 164:41-48.
25. Bolouki A, Zal F, Alaee S. Ameliorative effects of quercetin on the preimplantation embryos development in diabetic pregnant mice. J Obstet Gynaecol Res 2020; 46:736-744.
26. Chen M, Lin C, Liu CJC. Efficacy of phytoestrogens for menopausal symptoms: A meta-analysis and systematic review. Climacteric 2015; 18:260-269.
27. Grandi G, Facchinetti F, Melotti C, Sgandurra A. Phyto-progestins for the treatment of abnormal uterine bleeding without organic cause in women at high risk for breast cancer and breast cancer survivors: A prospective, pilot study. Gynecol Endocrinol 2023; 39:2239936.
28.Alshehri MM, Sharifi-Rad J, Herrera-Bravo J, Jara EL, Salazar LA, Kregiel D, et al. Therapeutic potential of isoflavones with an emphasis on daidzein. Oxid Med Cell Longev 2021; 2021; 6331630.
29. Jenks BH, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012; 21:674-682.
30. Unfer V, Casini ML, Costabile L, Mignosa M, Gerli S, Di Renzo GC. Endometrial effects of long-term treatment with phytoestrogens: A randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82:145-148.
31. Mohammad-Shahi M, Haidari F, Rashidi B, Saei AA, Mahboob S, Rashidi MR. Comparison of the effects of genistein and daidzein with dexamethasone and soy protein on rheumatoid arthritis in rats. Bioimpacts 2011; 1:161-170.
32. Vakili S, Zal F, Mostafavi-Pour Z, Savardashtaki A, Koohpeyma F. Quercetin and vitamin E alleviate ovariectomy-induced osteoporosis by modulating autophagy and apoptosis in rat bone cells. J Cell Physiol 2021; 236:3495-3509.
33. Yang Y, Zheng X, Li B, Jiang S, Jiang L. Increased activity of osteocyte autophagy in ovariectomized rats and its correlation with oxidative stress status and bone loss. Biochem Biophys Res Commun 2014; 451:86-92.
34. Martínez-Montemayor MM, Otero-Franqui E, Martinez J, De La Mota-Peynado A, Cubano LA, Dharmawardhane S. Individual and combined soy isoflavones exert differential effects on metastatic cancer progression. Clin Exp Metastasis 2010; 27:465-480.
35. Maghool F, Khaksari M. Differences in brain edema and intracranial pressure following traumatic brain injury across the estrous cycle: involvement of female sex steroid hormones. Brain Res 2013; 1497:61-72.
36. Jahromi BN, Farrokhnia F, Tanideh N, Kumar PV, Parsanezhad ME, Alaee S. Comparing the effects of glycyrrhiza glabra root extract, a cyclooxygenase-2 inhibitor (celecoxib) and a gonadotropin-releasing hormone analog (diphereline) in a rat model of endometriosis. Int J Fertil Steril 2019; 13:45-50.
37. Tanideh N, Daneshmand F, Karimimanesh M, Mottaghipisheh J, Koohpeyma F, Koohi-Hosseinabadi O, et al. Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats. Heliyon 2023; 9:e15557.
38. Aebi H. Catalase in vitro. Methods Enzymol 1984; 105:121-126.
39. Zal F, Mahdian Z, Zare R, Soghra B, Mostafavi-Pour Z. Combination of vitamin E and folic acid ameliorate oxidative stress and apoptosis in diabetic rat uterus. Int J Vitam Nutr Res 2014; 84:55-64.
40. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-254.
41. Teixeira CP, Simões RS, Santos MA, Calió ML, Soares JM, Jr., Simões MJ, et al. Soybean concentrated extract counteracts oxidative stress in the uterus of rats. Climacteric 2014; 17:402-409.
42. Zhao H, Li X, Li N, Liu T, Liu J, Li Z, et al. Long-term resveratrol treatment prevents ovariectomy-induced osteopenia in rats without hyperplastic effects on the uterus. Br J Nutr 2014; 111:836-846.
43. Lindberg MK, Weihua Z, Andersson N, Movérare S, Gao H, Vidal O, et al. Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol 2002; 174:167-178.
44. Lohrasbi P, Karbalay-Doust S, Mohammad Bagher Tabei S, Azarpira N, Alaee S, Rafiee B, Bahmanpour S. The effects of melatonin and metformin on histological characteristics of the ovary and uterus in letrozole-induced polycystic ovarian syndrome mice: A stereological study. Int J Reprod Biomed 2022; 20:973-988.
45. Ring KL, Mills AM, Modesitt SC. Endometrial hyperplasia. Obstet Gynecol 2022; 140:1061-1075.
46. Palmer J, Perunovic B, Tidy J. Endometrial hyperplasia. Obstet Gynaecol 2008; 10:211-216.
47. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, Uchiyama Y, et al. Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 1999; 140:1893-1900.
48. Hewitt SC, Korach KS. Estrogen receptors: New directions in the new millennium. Endocr Rev 2018; 39:664-675.
49. Kim JH, Kim YJ. Effects of genistein in combination with conjugated estrogens on endometrial hyperplasia and metabolic dysfunction in ovariectomized mice. Endocr J 2015; 62:531-542.
50. Zhang Y, Zhou LP, Li XL, Zhao YJ, Ho MX, Qiu ZC, et al. 8-Prenylgenistein, a prenylated genistein derivative, exerted tissue selective osteoprotective effects in ovariectomized mice. Oncotarget 2018; 9:24221-24236.
51. Hojnik M, Sinreih M, Anko M, Hevir-Kene N, Knific T, Pirš B, et al. The co-expression of estrogen receptors ERα, ERβ, and GPER in endometrial cancer. Int J Mol Sci 2023; 24:1-23.
52. Liu D-Y, He S-J, Jin E-H, Liu S-Q, Tang Y-G, Li S-H, Zhong L-T. Effect of daidzein on production performance and serum antioxidative function in late lactation cows under heat stress. Livest Sci 2013; 152:16-20.
53. Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, et al. Reliable identification of endometrial precancers through combined pax2, β-catenin, and pten immunohistochemistry. Am J Surg Pathol 2022; 46:404-414.
54. Raffone A, Travaglino A, Saccone G, Campanino MR, Mollo A, De Placido G, et al. Loss of PTEN expression as diagnostic marker of endometrial precancer: A systematic review and meta-analysis. Acta Obstet Gynecol Scand 2019; 98:275-286.
55. Mesa AM, Mao J, Nanjappa MK, Medrano TI, Tevosian S, Yu F, et al. Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation. Physiol Genomics 2020; 52:81-95.
56. Li LT, Jiang G, Chen Q, Zheng JN. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep 2015; 11:1566-1572.
57. Akbarzadeh‐Jahromi M, Jafari F, Parsanezhad ME, Alaee S. Evaluation of supplementation of cryopreservation medium with gallic acid as an antioxidant in quality of post‐thaw human spermatozoa. Andrologia 2022; 54:e14571.
58. Yousef MI, Kamel KI, Esmail AM, Baghdadi HH. Anti-oxidant activities and lipid lowering effects of isoflavone in male rabbits. Food Chem Toxicol 2004; 42:1497-1503.
)