Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle

Document Type : Original Article


1 1 College of Pharmaceutical Sciences, Hebei University, Baoding, China 2 Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China

2 College of Pharmaceutical Sciences, Hebei University, Baoding, China. NBP Pharmaceutical Company Limited, CSPC Pharmaceutical Group Limited, Shijiazhuang 052165, People’s Republic of China

3 1 College of Pharmaceutical Sciences, Hebei University, Baoding, China.3 NBP Pharmaceutical Company Limited, CSPC Pharmaceutical Group Limited, Shijiazhuang 052165, People’s Republic of China


Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability.
Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins.
Results: The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 μg/cm2/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits.
Conclusion: These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen.


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