Effect of Portulaca oleraceae L. extracts on the Morphine Dependence in Mice

Document Type : Original Article


1 Department of Pharmacodynamy and Toxicology, School of Pharmacy and Medical Research Toxicology Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Pharmacist


This study was initiated to investigate the effect of Portulaca oleraceae on morphine dependence in mice.
Materials and Methods
Dependence was induced using the subcutaneous injections of morphine for 3 days. On the day 4, morphine
injected 2 h prior to intraperitoneal injection of naloxone. The plant extracts ethanolic or aqueous
administered 0.5 h before the final dose of morphine. The number of jumping during the 30 min period after naloxone injection was considered as a measure of withdrawal syndrome.
Both extracts reduced the jumping episodes dose-dependently. The maximum effect was observed at doses
of 0.28 g/kg and 1.4 g/kg for the aqueous and ethanolic extracts, respectively. Clonidine and extracts
decreased the total activity in locomotion test.
These findings indicated that Portulacea oleraceae extracts can decrease morphine dependence in mice.


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